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8057 matches
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organism
protein
1)
Homo sapiens
ZBTB18 - Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2
inhibitors
of skeletal myogenesis. Also involved in controlling
cell
division
of progenitor
cells
and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May [...]
[a.k.a. XM_005273006, NP_991331.1, RP58]
2)
Homo sapiens
GPSM2 - G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Plays also an important role in asymmetric
cell
divisions
. Has guanine nucleotide dissociation
inhibitor
(GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity).
[a.k.a. R-HSA-388396, NM_001321039.2, NP_037428.3]
3)
Homo sapiens
TP53 - Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and
cell
type. Involved in
cell
cycle regulation as a trans-activator that acts to negatively regulate
cell
division
by controlling a set of genes required for this process. One of the activated genes is an
inhibitor
of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
[a.k.a. NM_001126113, ENSP00000481638, R-HSA-2559584]
4)
Homo sapiens
CENPF - Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential
inhibitor
of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during
cell
division
and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte
cell
cy [...]
[a.k.a. R-HSA-2555396, R-HSA-69278, R-HSA-69620]
5)
Homo sapiens
RBL2 - Retinoblastoma-like protein 2; Key regulator of entry into
cell
division
. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent
inhibitor
of E2F-mediated trans-activation, associates preferentially [...]
[a.k.a. XM_011523253, R-HSA-1362300, R-HSA-69278]
6)
Mus musculus
Zbtb18 - Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2
inhibitors
of skeletal myogenesis. Also involved in controlling
cell
division
of progenitor
cells
and regulating the survival of postmitotic cortical neurons. May [...]
[a.k.a. BC054529, UPI00053BD8BA, ENSMUSP00000076463]
7)
Mus musculus
Gpsm2 - G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric
cell
divisions
. Has guanine nucleotide dissociation
inhibitor
(GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family.
[a.k.a. ENSMUST00000124043, AK143552, ENSMUSP00000029482]
8)
Mus musculus
Trp53 - Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and
cell
type. Involved in
cell
cycle regulation as a trans-activator that acts to negatively regulate
cell
division
by controlling a set of genes required for this process. One of the activated genes is an
inhibitor
of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
[a.k.a. 3EXJ, R-MMU-453274, BC005448]
9)
Mus musculus
Rbl1 - Retinoblastoma-like protein 1; Key regulator of entry into
cell
division
(By similarity). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent
inhibitor
of E2F- mediated trans-activation (By simil [...]
[a.k.a. R-MMU-453279, AW547426, Q3U1D4]
10)
Mus musculus
Rbl2 - Retinoblastoma-like protein 2; Key regulator of entry into
cell
division
. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent
inhibitor
of E2F-mediated trans-activation, associates preferentially [...]
[a.k.a. NM_001282000, R-MMU-453279, mmu:19651]
11)
Drosophila melanogaster
pins - Partner of inscuteable (pins) encodes a GDP-dissociation
inhibitor
involved in asymmetric
cell
division
and mitotic spindle orientation.
[a.k.a. FBgn0040080, pins-PA, 4A1S]
12)
Drosophila melanogaster
CalpA - Calpain-A catalytic subunit; Calpain-A (CalpA) encodes a calcium-dependent modulatory protease that cleaves its substrates in a limited fashion. During patterning and
division
in the blastoderm embryo, CalpA product cleaves the NF-kappaB
inhibitor
and the
cell
cycle regulator encoded by cact and CycB, respectively. CalpA product also regulates dendritic prunning of sensory neurons.
[a.k.a. FBgn0012051, CalpA-PC, CalpA-PD]
13)
Drosophila melanogaster
Spn88Eb - CG6687 protein; Serine-type endopeptidase
inhibitor
activity. It is involved in the biological process described with: response to fungus; negative regulation of endopeptidase activity; epithelium regeneration; regulation of stem
cell
division
; negative regulation of proteolysis; Belongs to the serpin family.
[a.k.a. FBgn0038299, Spn88Eb-PA, NP_650427.1]
14)
Drosophila melanogaster
numb - Numb (numb) encodes a membrane-associated
inhibitor
of Notch signaling. It controls neuroblast and sense organ precursor asymmetric
division
. It is asymmetrically localized during mitosis and segregates exclusively to one of two daughter
cells
.
[a.k.a. FBgn0002973, numb-PD, numb-PA]
15)
Escherichia coli K12
sulA - SOS
cell
division
inhibitor
; Component of the SOS system and an
inhibitor
of
cell
division
. Accumulation of SulA causes rapid cessation of
cell
division
and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter
cells
during
cell
division
. The effect of overexpression of SulA is neutralized by antitoxin CbeA (yeeU).
[a.k.a. b0958, AAC74044.1, Cell division inhibitor SulA]
16)
Escherichia coli K12
slmA - Nucleoid occlusion factor, anti-FtsZ
division
inhibitor
; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and
cell
division
over the nucleoid. Acts as a DNA-associated
cell
division
inhibitor
that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
[a.k.a. b3641, AAC76665.2, Protein Ttk]
17)
Escherichia coli K12
minD -
Inhibitor
of FtsZ ring polymerization; ATPase required for the correct placement of the
division
site.
Cell
division
inhibitors
MinC and MinD act in concert to form an
inhibitor
capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the
cell
to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
[a.k.a. b1175, AAC74259.1, NP_415693]
18)
Escherichia coli K12
cbtA - CP4-44 prophage; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a dual toxin
inhibitor
that blocks
cell
division
and
cell
elongation in genetically separable interactions with FtsZ and MreB. Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization. Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockage of
cell
division
. Overexpression results in inhibition of growth in liquid cultures and decrease in col [...]
[a.k.a. b2005, AAC75066.1, yeeV]
19)
Escherichia coli K12
minC -
Inhibitor
of FtsZ ring polymerization;
Cell
division
inhibitor
that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the
cell
to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. Belongs to the MinC family.
[a.k.a. b1176, AAC74260.1, NP_415694]
20)
Escherichia coli K12
ypjF - CP4-57 prophage; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a dual toxin
inhibitor
that blocks
cell
division
and
cell
elongation in genetically separable interactions with FtsZ and MreB. Overexpression results in inhibition of growth in liquid cultures. Overexpression leads to formation of lemon-shaped
cells
; inactivated by overexpression of cognate antitoxin YfjZ but not when the 2 genes are coexpressed from the same plasmid. Also neutralized by overexpression of non-cognate antitoxins YafW and CbeA.
[a.k.a. b2646, AAC75694.1, 947131]
8057 matches
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